Axonal Transport Enables Neuron-to-Neuron Propagation of Human Coronavirus OC43
Identifieur interne : 000E40 ( Main/Exploration ); précédent : 000E39; suivant : 000E41Axonal Transport Enables Neuron-to-Neuron Propagation of Human Coronavirus OC43
Auteurs : Mathieu Dubé [Canada] ; Alain Le Coupanec [Canada] ; Alan H. M. Wong [Canada] ; James M. Rini [Canada] ; Marc Desforges [Canada] ; Pierre J. Talbot [Canada]Source :
- Journal of Virology [ 0022-538X ] ; 2018.
Abstract
Coronaviruses may invade the CNS, disseminate, and participate in the induction of neurological diseases. Their neuropathogenicity is being increasingly recognized in humans, and the presence and persistence of human coronaviruses (HCoV) in human brains have been proposed to cause long-term sequelae. Using our mouse model relying on natural susceptibility to HCoV OC43 and neuronal cell cultures, we have defined the most relevant path taken by HCoV OC43 to access and spread to and within the CNS toward the brain stem and spinal cord and studied in cell culture the underlying modes of intercellular propagation to better understand its neuropathogenesis. Our data suggest that axonal transport governs HCoV OC43 egress in the CNS, leading to the exacerbation of neuropathogenesis. Exploiting knowledge on neuroinvasion and dissemination will enhance our ability to control viral infection within the CNS, as it will shed light on underlying mechanisms of neuropathogenesis and uncover potential druggable molecular virus-host interfaces.
Url:
DOI: 10.1128/JVI.00404-18
PubMed: 29925652
PubMed Central: 6096804
Affiliations:
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Rini</name><affiliation wicri:level="4"><nlm:aff id="aff2">Department of Biochemistry, University of Toronto, Toronto, ON, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Biochemistry, University of Toronto, Toronto, ON</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="aff3">Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Molecular Genetics, University of Toronto, Toronto, ON</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Desforges, Marc" sort="Desforges, Marc" uniqKey="Desforges M" first="Marc" last="Desforges">Marc Desforges</name><affiliation wicri:level="1"><nlm:aff id="aff1">Laboratory of Neuroimmunovirology, INRS-Institut Armand-Frappier, Université du Québec, Laval, Québec, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Laboratory of Neuroimmunovirology, INRS-Institut Armand-Frappier, Université du Québec, Laval, Québec</wicri:regionArea><wicri:noRegion>Québec</wicri:noRegion></affiliation></author><author><name sortKey="Talbot, Pierre J" sort="Talbot, Pierre J" uniqKey="Talbot P" first="Pierre J." last="Talbot">Pierre J. Talbot</name><affiliation wicri:level="1"><nlm:aff id="aff1">Laboratory of Neuroimmunovirology, INRS-Institut Armand-Frappier, Université du Québec, Laval, Québec, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Laboratory of Neuroimmunovirology, INRS-Institut Armand-Frappier, Université du Québec, Laval, Québec</wicri:regionArea><wicri:noRegion>Québec</wicri:noRegion></affiliation></author></analytic><series><title level="j">Journal of Virology</title><idno type="ISSN">0022-538X</idno><idno type="eISSN">1098-5514</idno><imprint><date when="2018">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Coronaviruses may invade the CNS, disseminate, and participate in the induction of neurological diseases. Their neuropathogenicity is being increasingly recognized in humans, and the presence and persistence of human coronaviruses (HCoV) in human brains have been proposed to cause long-term sequelae. Using our mouse model relying on natural susceptibility to HCoV OC43 and neuronal cell cultures, we have defined the most relevant path taken by HCoV OC43 to access and spread to and within the CNS toward the brain stem and spinal cord and studied in cell culture the underlying modes of intercellular propagation to better understand its neuropathogenesis. Our data suggest that axonal transport governs HCoV OC43 egress in the CNS, leading to the exacerbation of neuropathogenesis. Exploiting knowledge on neuroinvasion and dissemination will enhance our ability to control viral infection within the CNS, as it will shed light on underlying mechanisms of neuropathogenesis and uncover potential druggable molecular virus-host interfaces.</p></div></front></TEI><affiliations><list><country><li>Canada</li></country><region><li>Ontario</li></region><settlement><li>Toronto</li></settlement><orgName><li>Université de Toronto</li></orgName></list><tree><country name="Canada"><noRegion><name sortKey="Dube, Mathieu" sort="Dube, Mathieu" uniqKey="Dube M" first="Mathieu" last="Dubé">Mathieu Dubé</name></noRegion><name sortKey="Desforges, Marc" sort="Desforges, Marc" uniqKey="Desforges M" first="Marc" last="Desforges">Marc Desforges</name><name sortKey="Le Coupanec, Alain" sort="Le Coupanec, Alain" uniqKey="Le Coupanec A" first="Alain" last="Le Coupanec">Alain Le Coupanec</name><name sortKey="Rini, James M" sort="Rini, James M" uniqKey="Rini J" first="James M." last="Rini">James M. Rini</name><name sortKey="Rini, James M" sort="Rini, James M" uniqKey="Rini J" first="James M." last="Rini">James M. Rini</name><name sortKey="Talbot, Pierre J" sort="Talbot, Pierre J" uniqKey="Talbot P" first="Pierre J." last="Talbot">Pierre J. Talbot</name><name sortKey="Wong, Alan H M" sort="Wong, Alan H M" uniqKey="Wong A" first="Alan H. M." last="Wong">Alan H. M. Wong</name><name sortKey="Wong, Alan H M" sort="Wong, Alan H M" uniqKey="Wong A" first="Alan H. M." last="Wong">Alan H. M. Wong</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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